Google DeepMind maps every possible DNA letter change in the human genome
AlphaGenome Atlas predictive map of every DNA letter change in the human genome
Google DeepMind has released AlphaGenome Atlas, a free platform predicting the molecular effects of all 9 billion possible single-letter DNA variants in the human genome. It combines AlphaGenome and AlphaMissense into a single AVI score, covering both coding and non-coding regions. Early collaborations found new rare disease variants and uncovered 22% more non-coding trait associations in UK Biobank data.
DNA is the language of life. Mastering it is a grand challenge that could transform our ability to understand biology and treat disease.
- Terr_
The Deus Ex game series is known for higher-effort discoverable in-game lore, and I think this e-mail from DXHR (2011) is relevant:
> We've been working with VersaLife’s new Chaos Model Genomatrix, which is trying to apply fractal mathematics to the study of genetic mutation. In essence, we've been trying to predict the future of human evolution using past mutations stored in the database of our mitochondria (which is passed uninterrupted from ancestral Eve through our mothers; it gives us an accurate and universal roadmap for our common past).
> The thing is… the sample you sent fits one of our evolutionary models of the future. We’re talking about someone who is ahead of the genetic curve by one step, maybe two. Do you know what this could mean for medicine alone? You have a living, breathing Nobel Prize on your hands!
(Megan Reed's computer, in the prologue.)
- BigTTYGothGF
Meanwhile someone went and did the experiment on the equivalent problem in a virus: https://www.science.org/content/blog-post/mutate-em-all-and-...
- jenders
If you like that abstract geometric headline image, you might also like the source artist their model “learned” it from: https://leegriggs.com/xgen-rendered-with-arnold-for-maya