Cialis: The erectile dysfunction drug that may help you live longer
Cialis is an erectile dysfunction drug. Could it also help you live longer?
Tadalafil (Cialis) is being promoted in wellness circles as a longevity drug, with observational studies linking it to lower risks of heart disease, dementia, and death. However, experts caution that these studies only show associations, not causation, and there are no randomized controlled trials in humans. Some online clinics now sell low-dose tadalafil for longevity, and a medical panel has endorsed its use for certain high-risk men, but others urge caution until better data exists.
Absence of evidence of harms doesn't mean there isn't harm.
- woliveirajr
Sildenafil [0] was synthesized to treat high blood pressure. Erectile disfunction was a side effect that raised much more interest.
Tadalafil [1] followed the path of Sildenafil about the phosphodiesterase type 5 (PDE5) enzyme inhibitor.
Help to live longer was the main objective since the beginning.
- Modified3019
FYI, before reaching for PDE5 inhibitors, please be aware that these seem to be ototoxic in some way. Common side effects are tinnitus and to a lesser extent hearing loss.
When taking these, you should track if there are changes to your hearing and cease immediately if you notice something. The damage seems cumulative and based on dose, and may resolve quickly, over months, or not at all. You should also look into any other medicines you take to see if they are ototoxic.
- miiiiiike
Check your blood pressure regularly.
Every time I read about a drug reducing dementia risk or increasing longevity I look it up to see if it lowers blood pressure. Never fails.
Cialis does.
- jurip
There was also just last week this study, which indicated a link to a higher risk of glaucoma: https://www.thepharmacist.co.uk/clinical/mens-health-clinica...
- francisofascii
Suprised this article doesn't mention nitric oxide or vasodilation? Is that how it works. It boosts nitric oxide signaling, acts as a vasodilator, and improves endothelial function. Beet juice, exercise, and eating nitrate-rich vegetables are some non-pharmaceutical ways to have a similar effect.